Anti-α1-antitrypsin (human, α1-AT, native and denatured)
Mouse monoclonal antibody
HYB 191-01 is specific for human α1-AT (native and denatured).
α1- AT isolated from human plasma
Species reactivity (positive)
Species reactivity (negative)
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
4-8ºC without exposure to light. No precautions necessary during handling.
The serum glycoprotein α1-antitrypsin also called α1-AT, is a typical member of the serpin family (serine protease inhibitors), and, an inhibitor of trypsin. α1-AT is synthesized in the liver thus as a single polypeptide chain of approximately 51 kDa showing a marked degree of genetic polymorphism due to the presence of over 20 different alleles. Individuals homozygous for α1-AT deficiency are predisposed to pulmonary emphysema and hepatic cirrhosis.