Anti-Acetylcholinesterase (human brain, bovine brain, AChE)

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Anti-Acetylcholinesterase (human brain, bovine brain, AChE)
368,00 $US

Availability: In stock

Anti-Acetylcholinesterase (human brain, bovine brain, AChE)
Description

Details

Cat. No.

 HYB 190-01

 Product name

 Anti-Acetylcholinesterase (human brain, bovine brain, AChE)

 Description

 Mouse monoclonal antibody

 Specificity

 HYB 190-01 is specific for brain AChE and does not recognize AChE from erythrocytes. The antibody can thus distinguish between mammalian brain AChE and erythrocyte AChE. 

 Immunogen

 C-terminal 10 residues of brain acetylcholinesterase (human and bovine), absent from the erythrocyte enzyme. 

 Application

 ELISA, WB, IHC

 Species reactivity (positive)

 Human, bovine, Torpedo marmorata

 Species reactivity (negative)

 Electric eel, human

 Subclass

  IgG1/l

Gene ID

 43, 540446

Clone number

 4E11

Epitope

C-terminal 10 residues (aa 574-583) of brain acetylcholinesterase (DS-AChE and SS-AChE) (1).

Content

 Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

 Protein-A purified

Form

Liquid

Solvent

 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

 4-8ºC without exposure to light. No precautions necessary during handling.

Target

 

Acetylcholinesterase (AChE, EC.3.1.1.7.) is an enzyme located in the postsynaptic membrane and in the muscle endplates, where it hydrolyses the neurotransmitter acetylcholin. AChE from brain is a tetramer (G4-AChE) with a molecular mass of 320 kDa, AChE from erythrocytes is a dimer (G2-AChE) with a molecular mass of 170 kDa.
Detection of higher levels of AChE in amniotic fluid can indicate fetal malformations such as neural tube defects.

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