Anti-MBL (rat, human)

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Anti-MBL (rat, human)
368,00 $US

Availability: In stock

Anti-MBL (rat, human)
Description

Details

Cat. No.

 HYB 131-18

 Product name

 Anti-MBL (rat, human)

 Description

 Mouse monoclonal antibody

 Specificity

 HYB 131-18 is specific for human MBL (mannan-binding lectin) from plasma or serum, but cross-reacts with MBL from rat.

 Immunogen

 MBL purified from human donor plasma

 Application

 ELISA, WB

 Species reactivity (positive)

 Rat, Human

 Species reactivity (negative)

 Not determined

 Subclass

  IgG1/k

Gene ID

 4153

Clone number

 11F11

Epitope

Not determined

Content

 Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification

 Protein-A purified

Form

Liquid

Solvent

 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

 4-8ºC without exposure to light. No precautions necessary during handling.

Target

 Mannan-binding lectin (MBL), also called mannose-binding lectin or protein, belongs to the C-type family of collectins, showing calcium-dependent binding to certain sugars. It consists of oligomers of triple-chain subunits and its binding and complement activating activities depend on its normal oligomerization. On binding to mannan-like microbial surface carbohydrates, MBL activates the complement system by means of its own lectin pathway, depending on the MBL-associated serine proteases (MASPs). Because of the presence of different structural and promoter alleles in the population, 12% or more of the population have low concentrations (<50ng/mL) of normally oligomerized, functional MBL in plasma or serum.
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