As part of the ECP 2014 symposium “Current Challenges in Breast Cancer Diagnostics,” Dr. Reis-Filho Surgical Pathologist, Division of Experimental Pathology, Department of Pathology, Memorial Sloan Kettering Cancer Center, presents hot topics within triple-negative breast cancers, highlighting the current thinking and clinical studies leading to a greater understanding of the disease and how this will ultimately impact the potential of targeted therapy for patients in the future.